Basal and Bolus Insulin Distribution According to Treatment Modality: Data from SWEET Diabetes Registry
Authors' conclusion
Herein, we showed that there was an association between lower proportions of basal to total insulin and lower hemoglobin A1c in a large cross-sectional cohort of children who had T1D. There was also an association between lower BD/TDD and younger age. There was no significant difference between BD/TDD ratios under different diabetes technologies (CGM and/or CSII).
Study context
- Population
- Children and adolescents aged 2.5–18 years with T1D for ≥2 years, ≥1 clinic visit June 2010–June 2021, SWEET registry; 48.6% female, median age 15.2 years
- Participants
- 38,956 children
- Exposure
- Insulin delivery and continuous glucose monitoring (CGM) use: Multiple daily injections (MDI) without CGM vs MDI with CGM vs CSII without CGM vs CSII with CGM
- Outcome
- Basal dose to total daily insulin dose ratio (BD/TDD) by treatment modality and diabetes technology
Methodological detailsregistry-based (SWEET)
- Registry-based (SWEET)
Main finding
As reported in the abstract
BD/TDD by treatment modality
- No association between BD/TDD and diabetes technologies after adjustment for age, gender and diabetes duration
- Unadjusted, in all modalities: male gender, younger age group and lower HbA1c associated with lower BD/TDD (all p < 0.05)
Observational data: associations, not effects.
Further findings
Distribution of treatment modality
Original publication
Basal and Bolus Insulin Distribution According to Treatment Modality: Data from SWEET Diabetes Registry. Pediatr Diabetes. Published 9 August 2023. doi:10.
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