Multimodal MRI neurodevelopmental profiling in type 1 diabetes: long-term effects of multiple daily injections (MDI) vs continuous subcutaneous insulin infusion (CSII) treatments
Authors' conclusion
Pediatric T1D is associated with multimodal neuroimaging alterations influenced by insulin treatment modality.
Study context
- Population
- Children with T1D and controls16 T1D children
- Exposure
- MDI vs CSII vs controls
- MDIn = 8
- CSIIn = 8
- Controlsn = eightreference
- Outcome
- Multimodal MRI features discriminating groups and links to HbA1c and WI repetition
Methodological detailsmultimodal MRI, machine-learning feature selection, mediation analysis
- Multimodal MRI
- Machine-learning feature selection
- Mediation analysis
Main finding
As reported in the abstract
- Functional vs structural features, balanced accuracy
- 0.83 vs 0.67
- Right inferior frontal gyrus (IFG) volume correlated with HbA1c
- r = 0.71, P < .05
- Right IFG volume predicted HbA1c
- β = 0.28, P = .015
- Higher HbA1c related to poorer WI repetition
- r = −0.60, P = .013
- Right IFG volume related to poorer WI repetition
- r = −0.70, P = .002
- Indirect HbA1c effect via right IFG volume (a × b), explaining ∼64% of total association
- −0.676; Sobel z = −1.765, one-tailed P = .0388
Observational data: associations, not effects.
Further findings
Mean rank
| Outcome | MDI | CSII | P value |
|---|---|---|---|
| WI repetition mean ranksCSII vs MDI | 5.81 | 11.19 | P = 0.023 |
- WI repetition mean ranks — CSII had lower hyperglycemia exposure than MDI
- 30%
Original publication
Multimodal MRI neurodevelopmental profiling in type 1 diabetes: long-term effects of MDI vs CSII treatments. J Clin Endocrinol Metab. Published 7 March 2026. doi:10.
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