Cardiovascular and renal diseases in type 2 diabetes patients: 5-year cumulative incidence of the first occurred manifestation and hospitalization cost: a cohort within the French SNDS nationwide claims database
Authors' conclusion
While MI, stroke and PAD remain classic major risks of complications for CVRD-free type 2 diabetes, HF and CKD nowadays represent individually a higher risk and cost than each of these classic manifestations, and jointly represents a risk and a cost twice as high as these three classic manifestations all together. This should encourage the development of specific HF and CKD preventive strategies.
Study context
- Population
- T2D patients free of cardiovascular renal diseases (CVRD) as of January 1st 2014 (no cancer or transplantation); mean age 65 years, 52% women, 7% with microvascular complications history76.5% of 2,079,089 CVRD-free
- Outcome
- Cumulative incidence of the first occurring CVRD manifestation (MI, stroke, PAD, HF, CKD) and cumulative hospitalization costs of each CVRD manifestation
- Follow-up
- 5 years
Methodological detailsFrench SNDS nationwide claims database, 5-year follow-up, death as competing risk
- French SNDS nationwide claims database
- 5-year follow-up
- Death as competing risk
Main finding
As reported in the abstract
Cumulative incidence of a first CVRD manifestation
- Cumulative incidence of first CVRD manifestation
- 15.3%
- Chronic kidney disease (CKD) share of first CVRD manifestations
- 40.6%
- Heart failure (HF) share
- 23.0%
- Peripheral arterial disease (PAD) share
- 13.5%
- Stroke share
- 13.2%
- Myocardial infarction (MI) share
- 9.7%
- HF and CKD together share of first CVRD manifestations
- 63.6%
Observational data: associations, not effects.
Further findings
Cumulative hospitalization costs of CVRD (all payers) · 5 years
- Global cost of all CVRD hospitalizations
- 3.9 billion euros
- Cost per patient of whole cohort
- 2,450€
- CKD
- 2.0 B€
- HF
- 1.2 B€
- PAD
- 0.7 B€
- Stroke
- 0.6 B€
- MI
- 0.3 B€
- Exponential increase over time for each specific CVRD manifestation
Original publication
Cardiovascular and renal diseases in type 2 diabetes patients: 5-year cumulative incidence of the first occurred manifestation and hospitalization cost: a cohort within the French SNDS nationwide claims database. Cardiovasc Diabetol. Published 9 January 2024. doi:10.
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