Cardiometabolic diseases and dynamic transitions of neuropsychiatric disorders: A longitudinal trajectory analysis
Authors' conclusion
CMDs could play important roles in basically all transitions of NPD progression, highlighting the significance of CMD management for the prevention and control of NPDs.
Study context
- Population
- UK Biobank participants; Cardiometabolic diseases (CMDs): T2D, hypertension, ischaemic heart disease and stroke; Neurological and psychiatric disorders (NPDs): dementia, Parkinson disease, anxiety, depression and sleep disordersUK Biobank
- Participants
- 402,950 participants
- Exposure
- Per additional CMD
- Outcome
- Transitions of NPD progression: healthy → first neuropsychiatric disease (FNPD) → neuropsychiatric multimorbidity (NPM, ≥2 NPDs) → death
- Follow-up
- Median 14.1 years
Methodological detailsmulti-state model
- Multi-state model
Main finding
As reported in the abstract
HR per additional CMD for NPD transitions
- Healthy → first neuropsychiatric disease (FNPD), HR
- 1.28 (1.26, 1.29) (95% CI)
- FNPD → neuropsychiatric multimorbidity (NPM), HR
- 1.07 (1.04, 1.10) (95% CI)
- Healthy → death, HR
- 1.38 (1.36, 1.40) (95% CI)
- FNPD → death, HR
- 1.19 (1.16, 1.23) (95% CI)
- NPM → death, HR
- 1.19 (1.13, 1.25) (95% CI)
- Developed ≥1 NPD
- 43 359
- Developed NPM
- 9087
- Died
- 31 307
Observational data: associations, not effects.
Further findings
Individual NPDs and single/combined CMDs
- Associations varied by disease type and specific CMD combinations, even within the same transition stage
Validation in China Health and Retirement Longitudinal Study cohort
- Confirmed associations between CMDs and NPDs
Original publication
Cardiometabolic diseases and dynamic transitions of neuropsychiatric disorders: A longitudinal trajectory analysis. Diabetes Obes Metab. Published 16 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →