Cardio-cerebrovascular Outcomes in Maturity Onset Diabetes of the Young (MODY), Type 1 Diabetes, and Type 2 Diabetes: A Prospective Cohort Study
Authors' conclusion
MODY diagnosed by genetic analysis represents higher prevalence than the clinical diagnosis in UK Biobank. The risk of incident cardio-cerebrovascular events in MODY ranks between type 1 diabetes and type 2 diabetes.
Study context
- Population
- Participants with diabetes from UK Biobank; T1D 2.7%, T2D 68.1%, MODY 11.4% of those with diabeteswith diabetes
- Participants
- 26,198 participants
- Exposure
- T1D, T2D and MODY vs people without diabetes
- Outcome
- First major adverse cardiovascular event (MACE): acute MI, HF, stroke, unstable angina pectoris, cardio-cerebrovascular-related mortality
- Follow-up
- Median 13 years
Main finding
As reported in the abstract
MACE
Control
1028
events
Type 1 diabetes
70
events
Type 2 diabetes
5020
events
MODY
717
events
Each group vs controlHazard ratio (95% CI)P value
Type 1 diabetes
2.15(1.69–2.74)
P < 0.05Type 2 diabetes
7.02(6.56–7.51)
P < 0.05MODY
5.79(5.26–6.37)
P < 0.05Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| MACE in MODY subgroups: HNF1B-MODY highestHNF1B-MODYvs Control | 11.00 (5.47–22.00) | P = 1.5 × 10-11 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Cardio-cerebrovascular Outcomes in MODY, Type 1 Diabetes, and Type 2 Diabetes: A Prospective Cohort Study. J Clin Endocrinol Metab. Published 24 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →