Candidate biomarkers as predictors of future kidney disease and cardiovascular dysfunction in adolescents with type 2 diabetes
Authors' conclusion
Circulating biomarkers of endothelial dysfunction and markers of β-cell dysfunction and insulin sensitivity could be used in a more personalized risk assessment of kidney disease in youth-onset type 2 diabetes. However, biomarkers studied have limited value in predicting cardiac dysfunction or vascular stiffness.
Study context
- Population
- Adolescents with T2D in the TODAY study; at baseline 35.7% male, mean age 13.9 years, diabetes duration 7.8 months, HbA1c 6.0%
- Participants
- 507 adolescents
- Primary endpoint
- Associations of circulating biomarkers with incident moderate albuminuria (UACR ≥ 30 mg/g), hyperfiltration (eGFR ≥ 135 mL/min/1.73 m² at two consecutive visits), and cardiac/vascular dysfunction (echocardiography, pulse wave velocity)
- Follow-up
- Mean 6.9 ± 2.4 years
Methodological detailscohort, longitudinal, annual biomarker assessment, Echocardiography (n = 256) and pulse wave velocity (n = 193) evaluated twice, 5 years apart
- Cohort
- Longitudinal
- Annual biomarker assessment
- Echocardiography (n = 256) and pulse wave velocity (n = 193) evaluated twice, 5 years apart
Primary result
As reported in the abstract
- Higher E-selectin and proinsulin associated with incident moderate albuminuria and hyperfiltration
- Higher FGF-23 associated with lower risk of hyperfiltration and negatively correlated with eGFR
- No candidate biomarker predicted a decline in cardiac or vascular function
- Adjusted Cox and logistic regression models
Original publication
Candidate biomarkers as predictors of future kidney disease and cardiovascular dysfunction in adolescents with type 2 diabetes. Diabetes Res Clin Pract. Published 15 April 2023. doi:10.
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