Dispersion of serum 1,5 anhydroglucitol values in patients with type 2 diabetes at goal of HbA1c
Authors' conclusion
Dispersion of 1,5 AG values at HbA1c < 7.5 % indicates postprandial glucose excursions that may impair glucose control and increase the cardiovascular risk in these patients.
Study context
- Population
- Outpatients with T2D ≥18 years old; median age 62.5 years, median 10 years with T2D
- Participants
- 100 outpatients
- Exposure
- HbA1c <7% vs HbA1c ≥7%
- Outcome
- Relationship of 1,5 AG with HbA1c across ranges of glycemic control
Main finding
As reported in the abstract
1,5 AG
HbA1c < 7 %
16.8
ug/ml
HbA1c ≥ 7 %
4.90
P = 0.00001
- 1,5 AG correlated inversely with HbA1c (r)
- −0.7910 (p = 0.00001)
Observational data: associations, not effects.
Further findings
Correlations of 1,5 AG with other variables
- Glycemia (r)
- −0.6307 (p = 0.00001)
- Cholesterol (r)
- −0.2257 (p = 0.0239)
- LDL-C (r)
- −0.2240 (p = 0.0266)
- Albuminuria (r)
- −0.3644 (p = 0.0002)
- Heart rate (r)
- −0.267 (p = 0.0072)
- All inverse correlations
1,5 AG by insulin therapy
- Lower 1,5 AG in those on insulin therapy
- P = 0.000
Original publication
Dispersion of serum 1,5 anhydroglucitol values in patients with type 2 diabetes at goal of HbA1c. Diabetes Res Clin Pract. Published 13 April 2023. doi:10. 1016/ j. diabres. 2023. 110668
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