Type 2 & other diabetes

Dispersion of serum 1,5 anhydroglucitol values in patients with type 2 diabetes at goal of HbA1c

Diabetes Res Clin PractPublished Cross-sectional study

Authors' conclusion

Dispersion of 1,5 AG values at HbA1c < 7.5 % indicates postprandial glucose excursions that may impair glucose control and increase the cardiovascular risk in these patients.

Study context

Population
Outpatients with T2D ≥18 years old; median age 62.5 years, median 10 years with T2D
Participants
100 outpatients
Exposure
HbA1c <7% vs HbA1c ≥7%
Outcome
Relationship of 1,5 AG with HbA1c across ranges of glycemic control

Main finding

As reported in the abstract

1,5 AG

HbA1c < 7 %

16.8

ug/ml

HbA1c ≥ 7 %

4.90

P = 0.00001

1,5 AG correlated inversely with HbA1c (r)
−0.7910 (p = 0.00001)

Observational data: associations, not effects.

Further findings

Correlations of 1,5 AG with other variables

Glycemia (r)
−0.6307 (p = 0.00001)
Cholesterol (r)
−0.2257 (p = 0.0239)
LDL-C (r)
−0.2240 (p = 0.0266)
Albuminuria (r)
−0.3644 (p = 0.0002)
Heart rate (r)
−0.267 (p = 0.0072)
  • All inverse correlations

1,5 AG by insulin therapy

Lower 1,5 AG in those on insulin therapy
P = 0.000

Original publication

Dispersion of serum 1,5 anhydroglucitol values in patients with type 2 diabetes at goal of HbA1c. Diabetes Res Clin Pract. Published 13 April 2023. doi:10.1016/j.diabres.2023.110668

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