Cancer risk according to fasting blood glucose trajectories: a population-based cohort study
Authors' conclusion
Our study highlights that the uncontrolled high glucose level for many years may increase the risk of cancer.
Study context
- Population
- Koreans aged 40–79 years with ≥3 health examinations 2002–2007, cancer-free before 2008, National Health Insurance Service-National Health Screening Cohort
- Participants
- 256,271 participants
- Exposure
- Fasting blood glucose (FBG) trajectories vs low-stable
- Outcome
- Cancer incidence by cancer type
- Follow-up
- 2008-2015
Methodological detailsgroup-based trajectory modeling, Cox proportional hazards model, adjusted for covariates
- Group-based trajectory modeling
- Cox proportional hazards model, adjusted for covariates
Main finding
As reported in the abstract
2008-2015
Each group vs low-stableHazard ratio (95% CI)
High-stablemultiple myeloma
4.09(1.40–11.95)
High-stableliver cancer
1.68(1.25–2.26)
High-stablegastrointestinal cancer
1.27(1.11–1.45)
Elevated-stableall cancer
1.08(1.02–1.16)
Elevated-stablestomach cancer
1.24(1.07–1.43)
Elevated-highoral cancer
2.13(1.01–4.47)
Elevated-highliver cancer
1.50(1.08–2.08)
Elevated-highpancreatic cancer
1.99(1.20–3.30)
- Cancer cases identified during follow-up
- 18,991
Observational data: associations, not effects.
Original publication
Cancer risk according to fasting blood glucose trajectories: a population-based cohort study. BMJ Open Diabetes Res Care. Published 27 February 2024. doi:10.
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