Bone Marrow Adiposity Alterations in Type 2 Diabetes Are Sex-Specific and Associated with Serum Lipid Levels
Authors' conclusion
In conclusion, our results suggest that marrow adiposity and composition are associated with lipid levels as well as T2D status, and these relationships are sex-specific.
Study context
- Population
- T2D patients and normoglycemic controls; single-voxel magnetic resonance spectroscopy (MRS) at spine and tibia
- Participants
- 39 vs 37
- Exposure
- T2D vs normoglycemic controls
- T2Dn = 39
- Controlsn = 37reference
- Outcome
- Associations of marrow adiposity and composition (MRS) with T2D status, serum lipid levels and sex
Methodological detailssex-stratified analyses, age-adjusted linear regression
- Sex-stratified analyses
- Age-adjusted linear regression
Main finding
As reported in the abstract
Spine marrow fat content (total, unsaturated, saturated)
- Total, unsaturated and saturated fat content at the spine lower in T2D vs controls in age-adjusted models; significant in men but not in women
- Adjustment for low-density lipoprotein (LDL), high-density lipoprotein (HDL) and statin use attenuated the association of T2D status with unsaturated fat but not saturated fat in men
- Positive association between LDL cholesterol and total marrow fat in male T2D; negative association between HDL and total marrow fat in female T2D
- Sex-stratified analyses
Observational data: associations, not effects.
Further findings
Serum lipids
- Total cholesterol, LDL and HDL lower in T2D vs controls
Original publication
Bone Marrow Adiposity Alterations in Type 2 Diabetes Are Sex-Specific and Associated with Serum Lipid Levels. J Bone Miner Res. Published 16 November 2023. doi:10.
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