Bone Accrual Trajectories in Children and Adolescents With Perinatal HIV Infection
Authors' conclusion
PHIV children had persistent deficits in all measures except height-adjusted spine BMD and BMC Z-scores. Data are needed on PHIV children followed to adulthood.
Study context
- Population
- Children and adolescents aged 7 to 16 years with perinatal HIV; US academic clinical research centers
- Participants
- 172 vs 1,321
- Exposure
- PHIV vs healthy Bone Mineral Density in Childhood Study (BMDCS) children
- PHIVn = 172
- BMDCSn = 1,321reference
- Outcome
- BMD/BMC Z-scores
Methodological detailscomparison with healthy reference cohort (BMDCS), piecewise weighted linear mixed effects models
- Comparison with healthy reference cohort (BMDCS)
- Piecewise weighted linear mixed effects models
Main finding
As reported in the abstract
BMD/BMC Z-scores across age
- Height-adjusted whole-body bone mineral density (BMD) and BMC Z-scores lower across age in PHIV vs BMDCS
- Spine BMD Z-score across age higher in PHIV after height adjustment
- Height-adjusted spine BMC Z-scores similar across age
- Adjusted for age, sex, race, height Z-score, and Tanner stage
Observational data: associations, not effects.
Further findings
- Whole-body and spine bone area tended to be lower in PHIV
- Slower accrual in whole-body and spine bone area in PHIV before 14 years
- Bone area accruals similar after 15 years
Original publication
Bone Accrual Trajectories in Children and Adolescents With Perinatal HIV Infection. J Clin Endocrinol Metab. Published 23 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →