The gSOS polygenic score is associated with bone density and fracture risk in childhood
Main finding · aBMD Z-scores across 7 skeletal sites (eg, LS aBMD Z-score) per 1 SD increase in gSOSResult — go to the resultHigher LS aBMD Z-score 0.17 95% CI 0.10–0.24Authors' conclusion
A higher gSOS score associated with higher aBMD at multiple skeletal sites and reduced odds of fracture in two independent pediatric samples.
Study context
- Population
- Children with genetic data in two observational studies (Bone Mineral Density in Childhood Study (BMDCS) and Children's Hospital of Philadelphia (CHOP))
- Participants
- 1,727 vs 10,301
- Exposure
- Per 1 SD increase in gSOS polygenic score
- BMDCSn = 1,727
- CHOPn = 10,301
- Outcome
- aBMD Z-scores (lumbar spine, hip, radius, whole body; DXA) and fracture
Methodological detailstwo pediatric cohorts, two independent samples, genetic association study
- Two pediatric cohorts
- Two independent samples
- Genetic association study
Main finding
As reported in the abstract
aBMD Z-scores across 7 skeletal sites (eg, LS aBMD Z-score) per 1 SD increase in gSOS
Higher LS Areal BMD (aBMD) Z-score
0.17
95% CI 0.10–0.24
Observational data: associations, not effects.
Further findings
Consistency of aBMD associations across subgroups
- Associations consistent for sex, age, puberty stage and lifestyle factors; most consistent in European genetic ancestry
Fracture association by sex and genetic ancestry
- No sex or genetic ancestry differences found
Original publication
The gSOS polygenic score is associated with bone density and fracture risk in childhood. J Bone Miner Res. Published 14 October 2025. doi:10.
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