Body weight variability as a predictor of cardiovascular outcomes in type 1 diabetes: A nationwide cohort study
Main finding · Composite of nonfatal MI, nonfatal stroke and all-cause mortalityResult — go to the resultHazard ratio 1.42 95% CI 1.24–1.62Authors' conclusion
High BWV is associated with an increased risk of CVD and all-cause mortality in individuals with T1D, independently of canonical risk factors. Weight trends, sex and glycaemic control do not modify such association while older age attenuates it.
Study context
- Population
- Individuals with T1D without CVD at baseline with ≥3 body weight measurements over three consecutive years, Swedish National Diabetes Registerof 36,333 in register
- Participants
- 19,373 individuals
- Exposure
- Highest vs lowest quartile of body weight variability
- Outcome
- Composite of:
- Nonfatal MI
- Nonfatal stroke
- All-cause mortality
- Follow-up
- 12.7 ± 4.6 year
Methodological detailsSwedish National Diabetes Register, adjusted Cox regression models
- Swedish National Diabetes Register
- Adjusted Cox regression models
Main finding
As reported in the abstract
Hazard ratio
1.42
95% CI 1.24–1.62
Highest BWVvs Lowest BWV
HR 1.42 (95% CI 1.24–1.62)
Observational data: associations, not effects.
Further findings
All-cause mortality
| HR (95% CI) | ||
|---|---|---|
| High BWV51% increased risk | 1.51 (1.28–1.78) | |
| 0.512Hazard ratio (log scale) |
Peripheral artery disease
| HR (95% CI) | ||
|---|---|---|
| High BWV37% increased risk | 1.37 (1.06–1.77) | |
| 0.512Hazard ratio (log scale) |
Hospitalization for HF
| HR (95% CI) | ||
|---|---|---|
| High BWV55% increased risk | 1.55 (1.20–2.01) | |
| 0.512Hazard ratio (log scale) |
Subgroups (weight trends, sex, glycaemic control, elderly)
- No interaction for weight trends, sex or degree of glycaemic control
- In elderly individuals, association of body weight variability (BWV) with primary endpoint no longer significant
Original publication
Body weight variability as a predictor of cardiovascular outcomes in type 1 diabetes: A nationwide cohort study. Diabetes Obes Metab. Published 28 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →