Body weight variability and the risk of liver‐related outcomes in type 2 diabetes and steatotic liver disease: a cohort study
Authors' conclusion
Increased BWV was associated with adverse liver outcomes in individuals with T2D and MASLD; however, in those who were physically active, it was not hazardous.
Study context
- Population
- Patients with T2D and MASLD with body weight variability (BWV) assessed during the first 2 years of follow-up
- Participants
- 549 patients
- Exposure
- Increasing body weight variability
- Outcome
- Adverse liver outcomes: clinical cirrhosis or liver stiffness on transient elastography > 15 kPa
- Follow-up
- Median 7 years after cohort entry
Methodological detailsmultivariable logistic regression, interaction/subgroup analyses by physical activity
- Multivariable logistic regression
- Interaction/subgroup analyses by physical activity
Main finding
As reported in the abstract
Higher odds of adverse liver outcome per 1-SD increase in weight SD and average real variability
52%
95% CI 4%–128%
Liver outcomes occurred (14 clinical cirrhosis, 20 liver stiffness > 15 kPa) over median 9.7 years
34
Observational data: associations, not effects.
Further findings
Subgroups by physical activity
- Increased BWV associated with higher likelihood of outcomes only in sedentary individuals
Original publication
Body weight variability and the risk of liver‐related outcomes in type 2 diabetes and steatotic liver disease: a cohort study. Obesity (Silver Spring). Published 25 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →