Body size, insulin sensitivity, metabolic health and risk of cardiovascular disease in Chinese adults: Insights from the China Cardiometabolic Disease and Cancer Cohort (4C) study
Authors' conclusion
This study emphasizes the need for refined definitions of metabolic health and advocates for meticulous screening for metabolic abnormalities to reduce cardiovascular risks, even in individuals with normal weight and insulin sensitivity.
Study context
- Population
- Chinese adults from the 4C Study
- Participants
- 115,638 adults
- Exposure
- Obese metabolically healthy vs normal-weight counterparts
- Outcome
- Composite of incident CVD:
- First MI
- Stroke
- HF
- Cardiovascular death
- Follow-up
- mean 3.61-year follow-up
Methodological detailsChina Cardiometabolic Disease and Cancer Cohort (4C) Study
- China Cardiometabolic Disease and Cancer Cohort (4C) Study
Main finding
As reported in the abstract
Incident CVD
Estimate (95% CI)
Obese, insulin sensitivevs Normal weight
multivariable-adjusted HR 1.69(1.37–2.08)
Obese, without metabolic syndromevs Normal weight
HR 1.46(1.13–1.89)
Obese, no metabolic abnormalitiesvs Normal weightsimilar CVD risk
HR 0.91(0.53–1.59)
Observational data: associations, not effects.
Further findings
Cardiovascular disease (CVD) risk by number of metabolic abnormalities
- CVD risk increased with the number of abnormalities across BMI categories, regardless of insulin sensitivity
Original publication
Body size, insulin sensitivity, metabolic health and risk of cardiovascular disease in Chinese adults: Insights from the China Cardiometabolic Disease and Cancer Cohort (4C) study. Diabetes Obes Metab. Published 28 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →