Body Composition and Metabolism in Adults With Molecularly Confirmed Silver-Russell Syndrome
Authors' conclusion
Adults with SRS have an unfavorable body composition and predisposition to cardiometabolic disease. These results support the need for a health surveillance strategy to mitigate adverse outcomes.
Study context
- Population
- Adults aged ≥ 18 years with molecularly confirmed Silver-Russell syndrome (SRS), research facilities across the UK; 52% female, median age 32.9 years (range, 22.0 to 69.7)52% female
- Participants
- 25 adults
- Exposure
- Adults with SRS vs unaffected men and women
- SRSn = 25
- Outcome
- Body composition
Methodological detailssingle appointment assessment, comparison with SWS cohort
- Single appointment assessment
- Comparison with SWS cohort
Main finding
As reported in the abstract
Body composition SRS median 44.1% · SWS median 30.3%
Fat mass index SRS 9.6 · SWS 7.8 · P = 0.3
Lean mass percentage
P < 0.001
Lean mass index SRS 13.5 kg/m² · SWS 17.3 kg/m² · P < 0.001
BMD SRS 1.08 · SWS 1.24 · P < 0.001
- SRS vs SWS: P < 0.001 — Fat percentage greater in SRS
Observational data: associations, not effects.
Further findings
Metabolic health in SRS
- Total cholesterol ≥ 5 mmol/L
- 52.0%
- TG ≥ 1.7 mmol/L
- 20.8%
- Fasting blood glucose ≥ 6.1 mmol/L
- 25.0%
- Hypertension
- 33.3%
Original publication
Body Composition and Metabolism in Adults With Molecularly Confirmed Silver-Russell Syndrome. J Clin Endocrinol Metab. Published 8 February 2024. doi:10.
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