Blood glucose fluctuation early after liver transplantation according to continuous glucose monitoring and its relationship with postoperative infection
Authors' conclusion
The study highlights the high prevalence of early postoperative hyperglycemia in liver transplant recipients and suggests that reduced TIR and increased TAR may elevate infection risks, particularly in patients with preoperative diabetes.
Study context
- Population
- Liver transplant recipients monitored with continuous glucose monitoring (CGM) for approximately one week post-transplantation during hospitalization
- Participants
- 95 recipients
- Exposure
- Liver transplant recipients with vs without diabetes
- Diabetesn = 37
- Without diabetesn = 58reference
- Outcome
- Incidence of early hyperglycemia
- Follow-up
- Approximately one week post-transplantation
Main finding
As reported in the abstract
Incidence of early hyperglycemia
100 %
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| CGM metrics: diabetes vs without diabetes | all P < 0.05 |
- CGM metrics: diabetes vs without diabetes: lower time in range (TIR); higher mean glucose, high blood glucose index (HBGI), maximal glucose and mean daily differences with Diabetes
Infections (pneumonia, intra-abdominal, bloodstream) in early post-transplant period
- Patients with infection
- 30.53 %
Factors for early infection in patients with diabetes
- TIR (independent protective factor), OR
- 0.865 (95% CI 0.765-0.970)
- Higher mean glucose (independent risk factor), OR
- 1.526 (95% CI 1.050-2.218)
- Time above range (TAR) (independent risk factor), OR
- 1.105 (95% CI 1.022-1.196)
Original publication
Blood glucose fluctuation early after liver transplantation according to continuous glucose monitoring and its relationship with postoperative infection. Diabetes Res Clin Pract. Published 6 November 2025. doi:10.
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