Real-Time Continuous Glucose Monitoring Improves Glycemic Control in the Early Postoperative Period Following Liver Transplantation: A Randomized Controlled Trial
Primary result · TIRResult — go to the resultMedian difference 7.2 percentage points 95% CI 2.7–12.0Authors' conclusion
Adding rtCGM to standard postoperative care improved glycemic control after liver transplantation, with consistent benefit regardless of diabetes status and the greatest effect on Level 2 hyperglycemia in patients with diabetes.
Study context
- Population
- Orthotopic liver transplantation recipients, early postoperative period142 analysed
- Participants
- 154 recipients
- Comparison
- Open real-time continuous glucose monitoring (rtCGM) vs blinded rtCGM
- Activen = 82
- Controln = 60reference
- Primary endpoint
- TIR (6.0-10.0 mmol/L)
Methodological detailssingle-centre
- Single-centre
Primary result
TIR
Median difference
7.2 percentage points
95% CI 2.7–12.0
P = 0.003
By group
Activevs Control
median difference 7.2 percentage points (95% CI 2.7–12.0); P = 0.003
As reported in the abstract
Secondary outcomes
| Outcome | Incidence rate ratio (CI) | P value | |
|---|---|---|---|
| Extended hyperglycemic episodes | 1.65 (1.03–2.65) | P = 0.039 | |
| 0.20.5125Incidence rate ratio (log scale) |
Infectious complications
P = 0.041
- Time in Level 1 hyperglycemia · less time with Active
- P = 0.025
TIR by pretransplant diabetes status
- TIR improved similarly in patients with and without pretransplant diabetes
Level 2 hyperglycemia, treatment-by-diabetes interaction
- Greater reduction in Level 2 hyperglycemia among patients with diabetes (only significant interaction)
- P < 0.001
Safety
Infectious complications
P = 0.041
Hypoglycemia
- Hypoglycemia was minimal in both groups
Original publication
Real-Time Continuous Glucose Monitoring Improves Glycemic Control in the Early Postoperative Period Following Liver Transplantation: A Randomized Controlled Trial. Diabetes Technol Ther. Published 24 August 2026. doi:10.
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