Blood coagulation in Prediabetes clusters–impact on all-cause mortality in individuals undergoing coronary angiography
Main finding · Risk of deathResult — go to the resultHazard ratio 1.30 CI 1.01–1.67Authors' conclusion
High-risk prediabetes clusters are associated with prothrombotic changes in the coagulation system that likely contribute to the increased mortality in those individuals at cardiometabolic risk. The hypercoagulable state observed in the high-risk clusters indicates an increased risk for cardiovascular and thrombotic diseases that should be considered in future risk stratification and therapeutic strategies.
Study context
- Population
- Participants without diabetes undergoing coronary angiography, LURIC study, assigned to prediabetes clusters using OGTT-derived glucose and insulin, HDL-C, TG and anthropometric data
- Participants
- 917 participants
- Exposure
- High-risk vs low-risk prediabetes clusters
- High-risk clustersn = 274
- Low-risk clustersn = 643reference
- Outcome
- All-cause mortality
Methodological detailsanalysis of the LURIC study, mediation analysis, proportional hazards models
- Analysis of the LURIC study
- Mediation analysis
- Proportional hazards models
Main finding
Risk of death
Hazard ratio
1.30
CI 1.01–1.67
High-risk clustersvs Low-risk clusters
HR 1.30 (CI 1.01–1.67)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Coagulation parameters
- Significantly elevated procoagulant factors (fibrinogen, FVII/VIII/IX), D-dimers, vWF and PAI-1 in high-risk vs low-risk clusters
Coagulation factors and mortality
- Elevated fibrinogen, D-dimers, FVIII and vWF associated with increased risk of death
- Adjusted for relevant confounders
Mediation analysis
- vWF significantly mediates the cluster-specific risk of death
Original publication
Blood coagulation in Prediabetes clusters–impact on all-cause mortality in individuals undergoing coronary angiography. Cardiovasc Diabetol. Published 22 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →