Bidirectional association between type 2 diabetes and irritable bowel syndrome: A large‐scale prospective cohort study
Authors' conclusion
T2D and IBS exhibit a bidirectional association, with an increased risk of co-morbidity. Awareness of this association may improve the prevention and management of both diseases.
Study context
- Population
- UK Biobank participants; diagnoses by ICD-10 codes
- Participants
- 11,140 / 413,979 / 21,944 / 413,979
- Exposure
- T2D vs non-T2D; Irritable bowel syndrome (IBS) vs non-IBS
- T2Dn = 11,140
- non-T2Dn = 413,979reference
- IBSn = 21,944
- non-IBSn = 413,979reference
- Outcome
- Incident IBS (cohort 1) and incident T2D (cohort 2)
- Follow-up
- median 14.5-year follow-up
Methodological detailspopulation-based, UK Biobank, bidirectional analysis, Cox proportional hazards model
- Population-based
- UK Biobank
- Bidirectional analysis
- Cox proportional hazards model
Main finding
As reported in the abstract
Incident IBS (cohort 1); incident T2D (cohort 2)
Adjusted hazard ratio (95% CI)P value
T2Dvs non-T2Dincident IBS; 8984 IBS cases
1.39(1.23–1.56)
P < 0.001IBSvs non-IBSincident T2D; 29 563 T2D cases
1.18(1.12–1.24)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident IBS in T2D with higher fasting blood glucoseT2Dvs non-T2DHigher fasting blood glucose | 1.43 (1.19–1.72) | P < 0.001 | |
| Incident IBS in T2D with longer T2D durationT2Dvs non-T2DLonger T2D duration | 1.47 (1.23–1.74) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Incident T2D by IBS duration
- Similar excess T2D risk with IBS duration <10 years or ≥10 years
Sensitivity and subgroup analyses
- Consistent findings
Original publication
Bidirectional association between type 2 diabetes and irritable bowel syndrome: A large‐scale prospective cohort study. Diabetes Obes Metab. Published 20 August 2024. doi:10.
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