Bisphosphonate use is associated with reduced fracture rates in a cohort of patients with Parkinson’s disease
Authors' conclusion
In the regression analysis with landmark model with 5806 patients, higher age, heavy alcohol consumption, smoking, and history of solid tumor were significant risk factors of osteoporotic fractures. Higher weight was a significant preventative factor.
Study context
- Population
- Patients with Parkinson's disease and osteoporosis, South Korea, 2002 to 20185,806 in landmark model
- Participants
- 7,335 patients
- Exposure
- Bisphosphonate use vs no bisphosphonate use
- Outcome
- Occurrence of osteoporotic fracture
Methodological detailsnationwide (Korea National Health Insurance Service database), landmark model 1 year after osteoporosis diagnosis
- Nationwide (Korea National Health Insurance Service database)
- Landmark model 1 year after osteoporosis diagnosis
Main finding
As reported in the abstract
Osteoporotic fracture with bisphosphonate use (landmark model, 1 year after osteoporosis diagnosis)
Bisphosphonate use, HR
0.83
95% CI 0.73–0.96p = 0.012
Observational data: associations, not effects.
Further findings
Risk factors for osteoporotic fracture (index regression model)
- Higher age, larger waist circumference, smoking and history of lymphoma were significant risk factors
- Higher weight and higher physical activity score were significant preventative factors
Risk factors for osteoporotic fracture (landmark model)
- Higher age, heavy alcohol consumption, smoking and history of solid tumor were significant risk factors
- Higher weight was a significant preventative factor
Original publication
Bisphosphonate use is associated with reduced fracture rates in a cohort of patients with Parkinson’s disease. Osteoporos Int. Published 23 February 2026. doi:10.
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