Combined effect of MASLD and low muscle strength on the risk of osteoporotic fractures: A UK Biobank cohort study
Authors' conclusion
Fracture risk in individuals with MASLD was increased only when LMS coexisted. These findings highlight the importance of incorporating muscle health assessment into the clinical evaluation of MASLD to improve risk stratification.
Study context
- Population
- UK Biobank participants; median age 57 years, 52.1% women4,919 fracture events
- Participants
- 191,176 participants
- Exposure
- MASLD and/or low muscle strength vs neither
- Outcome
- Incident osteoporotic fractures
- Follow-up
- Median 13.4 years
Methodological detailslarge-scale, UK Biobank
- Large-scale
- UK Biobank
Main finding
As reported in the abstract
Each group vs controlAdjusted hazard ratio (95% CI)
MASLD onlynot associated with higher fracture risk
1.00(0.90–1.10)
LMS only
1.14(1.06–1.22)
MASLD with LMSgreatest fracture risk, particularly women
1.23(1.10–1.38)
Observational data: associations, not effects.
Original publication
Combined effect of MASLD and low muscle strength on the risk of osteoporotic fractures: A UK Biobank cohort study. Eur J Endocrinol. Published 23 February 2026. doi:10.
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