Interactions Between HR‐pQCT Bone Density and D 3 Cr Muscle Mass (or HR‐pQCT Bone Structure and HR‐pQCT Muscle Density) in Predicting Fractures: The Osteoporotic Fractures in Men Study
Authors' conclusion
In this prospective cohort study of older men, there was no consistent interactions between bone and muscle variables on fracture risk.
Study context
- Population
- Older men in the Osteoporotic Fractures in Men study; mean age 84.2 ± 4.0 years, 92.7% white; followed 6.03 ± 2.11 years
- Participants
- 1,353 men
- Exposure
- Interaction between bone and muscle in predicting fractures
- Outcome
- Incident fractures (all, nonvertebral, vertebral), self-reported every 4 months and centrally adjudicated by physician review of radiology reports
Methodological detailsCox proportional hazards models, continuous and quartile analyses
- Cox proportional hazards models
- Continuous and quartile analyses
Main finding
As reported in the abstract
- No interactions between any muscle variable (D3Cr muscle mass, muscle volume, muscle density, grip strength or leg force) and Tt.BMD at distal radius/tibia for fractures
- p > 0.05
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All fracturesQ1 D3Cr muscle mass and Q1 distal tibia Tt.BMDvs Q2-4 D3Cr muscle mass and Q2-4 distal tibia Tt.BMDMultivariable-adjusted model | 2.00 (1.24–3.23) | P = 0.005 | |
| Nonvertebral fracturesQ1 D3Cr muscle mass and Q1 distal tibia Tt.BMDvs Q2-4 D3Cr muscle mass and Q2-4 distal tibia Tt.BMDMultivariable-adjusted model | 2.10 (1.25–3.52) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Other quartile groups
- CIs overlapped on visual inspection of other quartile groups
- P > 0.05
- Multivariable-adjusted model
Original publication
Interactions Between HR‐pQCT Bone Density and D 3 Cr Muscle Mass (or HR‐pQCT Bone Structure and HR‐pQCT Muscle Density) in Predicting Fractures: The Osteoporotic Fractures in Men Study. J Bone Miner Res. Published 13 July 2023. doi:10.
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