Baseline Computed Tomography Coronary Angiography and Polygenic Risk Profiles in Adults With Type 2 Diabetes: A Cross‐Sectional Analysis From the VOLTAIRE Study
Authors' conclusion
Substantial heterogeneity and limited overlap exist between anatomical, genetic, and clinical cardiovascular risk measures in T2D.
Study context
- Population
- Adults with T2D who completed baseline computed tomography coronary angiography (CTCA) and polygenic risk score (PRS) assessment prior to randomisation in the VOLTAIRE study; mean age 57.5 ± 8.7 years, 62.7% male
- Participants
- 126 adults
- Outcome
- Baseline anatomical, genetic and clinical cardiovascular risk profiles
- Follow-up
- Baseline
Methodological detailsbaseline analysis of a randomised study (VOLTAIRE)
- Baseline analysis of a randomised study (VOLTAIRE)
Main finding
As reported in the abstract
- Coronary artery calcium (CAC) = 0
- 34.9%
- CAC ≥ 400
- 19.8%
- Moderate-to-severe coronary stenosis (≥ 50%), overall
- 40.5%
- Moderate-to-severe coronary stenosis (≥ 50%) among those at low clinical risk
- 20.4%
- PRS low tertile
- 37.3%
- PRS intermediate tertile
- 35.7%
- PRS high tertile
- 27.0%
- High risk across all three domains (anatomical, genetic, clinical)
- 8.7%
Observational data: associations, not effects.
Original publication
Baseline Computed Tomography Coronary Angiography and Polygenic Risk Profiles in Adults With Type 2 Diabetes: A Cross‐Sectional Analysis From the VOLTAIRE Study. Diabetes Obes Metab. Published 8 July 2026. doi:10.
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