Baseline and longitudinal changes of body roundness index and incident type 2 diabetes: evidence from the UK Biobank cohort
Authors' conclusion
This study shows that both baseline BRI and long-term BRI changes are linked to T2D risk, emphasizing the significance of monitoring BRI trends for T2D prevention and control.
Study context
- Population
- UK Biobank adults aged 37–73 years32,956 developed T2D
- Participants
- 485,509 adults
- Exposure
- Baseline body roundness index (BRI) tertiles and long-term BRI changes
- Outcome
- Incident T2D
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
Incident T2D by baseline BRI
Adjusted hazard ratio (95% CI)
Second tertile
2.39(2.28–2.51)
Third tertile
6.23(5.96–6.50)
Observational data: associations, not effects.
Further findings
Incident T2D by long-term BRI grade change (longitudinal analysis, n = 65 684; 1153 T2D cases)
| HR (95% CI) | ||
|---|---|---|
| Low baseline BRI, grade increase | 1.49 (1.05–2.13) | |
| 0.512Hazard ratio (log scale) |
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident T2D by long-term BRI grade change (longitudinal analysis, n = 65 684; 1153 T2D cases)Middle baseline BRI, grade decreasevs Stable middle | 0.65 (0.45–0.93) | |
| Incident T2D by long-term BRI grade change (longitudinal analysis, n = 65 684; 1153 T2D cases)Middle baseline BRI, grade increasevs Stable middle | 1.66 (1.32–2.10) | |
| Incident T2D by long-term BRI grade change (longitudinal analysis, n = 65 684; 1153 T2D cases)High baseline BRI, grade decreasevs Stable high | 0.50 (0.40–0.62) | |
| 0.512Hazard ratio (log scale) |
Annual average rate of change (AARC) of BRI and T2D risk
- Non-linear associations between AARC of BRI and T2D risk
- P < 0.05
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Baseline and longitudinal changes of body roundness index and incident type 2 diabetes: evidence from the UK Biobank cohort. BMJ Open Diabetes Res Care. Published 15 September 2025. doi:10.
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