Associations of sphingosine-1-phosphate with thyroid function and structure: a cross-sectional population-based study
Authors' conclusion
Circulating S1P is inversely associated with TSH and positively associated with fT3, suggesting a potential modulatory role of S1P in thyroid function.
Study context
- Population
- Participants of the population-based Study of Health in Pomerania, Northeast Germany; 51.6% women, aged 20–84 years
- Participants
- 4,034 participants
- Exposure
- Serum S1P levels vs thyroid function and structure markers
- Outcome
- Associations of S1P (per 1 μmol/L higher) with thyroid function
Methodological detailspopulation-based, multivariable linear regression adjusted for confounding
- Population-based
- Multivariable linear regression adjusted for confounding
Main finding
As reported in the abstract
TSH: lower per 1 μmol/L higher S1P, mIU/L
0.17
95% CI −0.32; −0.04
FT3: higher per 1 μmol/L higher S1P, pmol/L (0.42; 0.63)
0.52
Observational data: associations, not effects.
Further findings
Thyroid structure on US
- Higher S1P associated with larger thyroid volume, presence of thyroid nodules and hypoechogenic thyroid pattern
Original publication
Associations of sphingosine-1-phosphate with thyroid function and structure: a cross-sectional population-based study. Eur Thyroid J. Published 22 June 2026. doi:10.
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