Diagnostic value of the thyrotropin-releasing hormone (TRH) test for central hypothyroidism in patients with pituitary and parasellar tumors: a single-center retrospective cross-sectional study
Authors' conclusion
In this study, we revealed that CeH can be diagnosed with a TRH test with a probability of more than 90%, and the test may be useful for diagnosing the CeH in patients with normal fT4 levels.
Study context
- Population
- Patients who underwent TRH test (200 µg), with or without pituitary and parasellar tumors
- Participants
- 105 patients
- Exposure
- TRH test responses in central hypothyroidism (CeH) vs controls vs PPTs with normal FT4
- Group 1n = 25reference
- Group 2n = 13
- Group 3n = 67
- Outcome
- TSH values and responses after TRH test
Methodological detailssingle-centre, retrospective
- Single-centre
- Retrospective
Main finding
As reported in the abstract
False-positive rate using two or more cut-off values
4%
Observational data: associations, not effects.
Further findings
- Group 3 had a higher rate of positive results than Group 1, suggesting hidden CeH
Original publication
Diagnostic value of the TRH test for central hypothyroidism in patients with pituitary and parasellar tumors: a single-center retrospective cross-sectional study. Pituitary. Published 20 August 2026. doi:10.
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