Clinical characteristics, surgical and endocrinological outcomes of sellar and parasellar masses in pediatric patients: a single-center experience
Authors' conclusion
Surgical management of pediatric sellar and parasellar masses carries significant risk of endocrinological complications, particularly panhypopituitarism. A multidisciplinary approach combining appropriate surgical technique selection, comprehensive endocrinological evaluation, and long-term follow-up is essential for optimal patient outcomes. Non-pituitary masses, especially craniopharyngioma, are associated with higher morbidity and mortality rates.
Study context
- Population
- Pediatric patients who underwent surgery for sellar and parasellar masses, January 2021–January 2025, followed in pediatric endocrinology clinic; 59.6% female, median age 10.1 years (range 2.5–17.5)
- Participants
- 47 patients
- Exposure
- Non-pituitary vs pituitary tumors
- Non-pituitaryn = 35
- Outcome
- Clinical characteristics, surgical and endocrinological outcomes
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Presenting complaint: headache
- 46.8%
- Presenting complaint: visual impairment
- 27.7%
- Presenting complaint: short stature
- 14.9%
- Non-pituitary masses
- 35 (74.5%)
- Craniopharyngioma
- 44.7%
- Endoscopic approach
- 42 (89.4%)
- Total resection
- 30 (63.8%)
- Postoperative panhypopituitarism (vs preoperative 10.6%, p < 0.001)
- 27 (57.4%)
- Recurrence (median follow-up 2.5 years)
- 10 (21.3%)
- Mortality (median follow-up 2.5 years)
- 11 (23.4%)
Observational data: associations, not effects.
Further findings
Re-operation
P = 0.012
Mortality
P = 0.024
Safety
Postoperative panhypopituitarism
- Panhypopituitarism postoperatively vs preoperative 10.6% (p < 0.001)
- 27 (57.4%)
Original publication
Clinical characteristics, surgical and endocrinological outcomes of sellar and parasellar masses in pediatric patients: a single-center experience. Pituitary. Published 22 September 2025. doi:10.
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