Associations of lactate dehydrogenase with risk of renal outcomes and cardiovascular mortality in individuals with diabetic kidney disease
Main finding · ESRD (Cohort 1)Result — go to the resultHazard ratio 2.11 95 % CI 1.07–4.16Authors' conclusion
LDH levels are associated with renal injury and progression to ESRD, as well as being an independent risk factor for cardiovascular in individuals with DKD.
Study context
- Population
- Individuals with Diabetic Kidney Disease (DKD); Cohort 1 and NHANES-based Cohort 2two cohorts
- Exposure
- Higher vs lower lactate dehydrogenase (LDH)
- Outcome
- End-stage renal disease (ESRD)
Methodological detailstwo cohorts, NHANES validation cohort
- Two cohorts
- NHANES validation cohort
Main finding
ESRD (Cohort 1)
Hazard ratio
2.11
95 % CI 1.07–4.16
Higher LDHvs Lower LDH
HR 2.11 (95 % CI 1.07–4.16)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Albumin-creatinine ratio (ACR) (Cohort 2)
- LDH and ACR level, linear regression β
- β = 2.95, P = 0.001
Cardiovascular mortality per 1-SD increase in LDH (Cohort 2)
- HR per 1-SD increase in LDH (27 % increased risk), multivariate Cox regression
- HR = 1.27; 95 % CI, 1.09-1.48
Original publication
Associations of lactate dehydrogenase with risk of renal outcomes and cardiovascular mortality in individuals with diabetic kidney disease. Diabetes Res Clin Pract. Published 20 July 2023. doi:10.
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