Glucagon prescribing and prevention of hospitalization for hypoglycemia in a large health system
Main finding · Hospitalized for hypoglycemiaResult — go to the resultAdjusted incidence rate ratio 1.71 95% CI 1.10–2.66Authors' conclusion
Glucagon prescribing was infrequent with significant racial and rural disparities. Patients with glucagon prescriptions did not have lower rates of hospitalization for hypoglycemia.
Study context
- Population
- Adults (≥18 years) with T1D, or T2D treated with short-acting insulin and/or recent hypoglycemia-related ED visit or hospitalization; large integrated healthcare system, May 2019–August 2021
- Participants
- 9,200 high risk adults
- Exposure
- Glucagon prescribed vs not prescribed
- Prescribed glucagonn = 1,707
- Not prescribed glucagonn = 1,707reference
- Outcome
- Hypoglycemia-related hospitalization
Methodological detailselectronic health records, matched 1:1
- Electronic health records
- Matched 1:1
Main finding
Hospitalized for hypoglycemia
Adjusted incidence rate ratio
1.71
95% CI 1.10–2.66
P = 0.018
Events by group
Prescribed glucagon
62
events
Not prescribed glucagon
33
events
Prescribed glucagonvs Not prescribed glucagon
adjusted incidence rate ratio 1.71 (95% CI 1.10–2.66); P = 0.018
As reported in the abstract
Observational data: associations, not effects.
Further findings
Glucagon prescribing
- Prescribed glucagon among high risk adults
- 2063 (22.4%)
- More likely prescribed: younger, female, White, urban, prior severe hypoglycemia, recent endocrinology specialist visit
Original publication
Glucagon prescribing and prevention of hospitalization for hypoglycemia in a large health system. Diabetes Res Clin Pract. Published 13 July 2023. doi:10.
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