Associations of Glycemic Measures in the Normal Range With All-Cause Mortality in the Absence of Traditional Risk Factors
Main finding · All-cause mortality by normal 2-hour glucoseResult — go to the resultHazard ratio 1.80 95% CI 1.03–3.15Authors' conclusion
Among US adults without traditional risk factors, high normal 2-hour glucose level was positively associated with all-cause mortality. This result highlights the potential importance of maintaining a lower normal level of 2-hour glucose for preventing mortality in individuals who are conventionally considered to be cardiovascular healthy.
Study context
- Population
- Nonpregnant US adults (NHANES 1988–1994 and 1999–2018) with 2-hour glucose, FPG and HbA1c measured and no traditional risk factors
- Exposure
- Normal-range FPG, HbA1c and 2-hour glucose categories and all-cause mortality
- Outcome
- All-cause mortality
Methodological detailsCox proportional hazard models
- Cox proportional hazard models
Main finding
All-cause mortality by normal 2-hour glucose
Hazard ratio
1.80
95% CI 1.03–3.15
2-hour glucose 110-139 mg/dLvs 2-hour glucose <80 mg/dL
HR 1.80 (95% CI 1.03–3.15)
As reported in the abstract
Observational data: associations, not effects.
Further findings
All-cause mortality by normal 2-hour glucose, subgroups
- Significant associations also found among people aged ≥60 years and men
All-cause mortality by normal FPG and HbA1c
- No significant associations between normal FPG and HbA1c levels and all-cause mortality
- Normal FPG n = 5793; normal HbA1c n = 8179
Original publication
Associations of Glycemic Measures in the Normal Range With All-Cause Mortality in the Absence of Traditional Risk Factors. J Clin Endocrinol Metab. Published 6 August 2024. doi:10.
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