Economic Burden of Endometrial Cancer Associated With Polycystic Ovary Syndrome
Authors' conclusion
The excess annual US healthcare cost for EndoCA attributable to PCOS exceeds $467 million/year (2023 USD). Although a concerning morbidity of PCOS, it is notable that the economic burden of EndoCA attributable to the disorder represents only a small fraction of its total healthcare burden.
Study context
- Population
- Studies with controls on endometrial cancer rates in patients with polycystic ovary syndrome (PCOS); US cost estimate9 studies
- Comparison
- PCOS vs no PCOS
- Outcome
- Economic burden associated with endometrial cancer in PCOS (excess cost, USD)
Methodological detailsPRISMA, Newcastle-Ottawa Scale quality assessment, DerSimonian-Laird random effects model
- PRISMA
- Newcastle-Ottawa Scale quality assessment
- DerSimonian-Laird random effects model
Pooled result
As reported in the abstract
Economic burden of endometrial cancer attributable to PCOS (US)
Estimated costs of endometrial cancer (2023 US dollars (USD))
exceeding $1.9 billion
Economic burden of endometrial cancer attributable to PCOS
exceeds $467 million/year
Population attributable fraction of endometrial cancer for PCOS
24.4%
Further pooled results
| Outcome | Pooled RR (95% CI) | P value | |
|---|---|---|---|
| Endometrial cancer risk in PCOSRandom effects model | 3.46 (2.28–5.23) | P ≤ 0.001 | |
| 0.20.5125Pooled relative risk (log scale) |
| Outcome | PCOS |
|---|---|
| US prevalence of endometrial cancer, 2020 | 1.712% |
- US prevalence of endometrial cancer, 2020 — Baseline estimated prevalence in all women
- 0.489%
- US prevalence of endometrial cancer, 2020 — Excess prevalence attributable to PCOS
- 1.223%
- US prevalence of endometrial cancer, 2020 — Affected women (approximately)
- 98 348
Original publication
Economic Burden of Endometrial Cancer Associated With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. Published 6 August 2024. doi:10.
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