Association of Initial and Changes in Serum Adipocyte Fatty Acid-binding Protein (A-FABP) Level With the Development and Improvement of Presarcopenia
Authors' conclusion
Baseline serum A-FABP level and its changes were positively associated with the incidence and negatively associated with the improvement of presarcopenia.
Study context
- Population
- Community-based adults (41.2% men; median age 58 [53–63] years), 2013–2014, followed up to 2015–2016; presarcopenia = skeletal muscle index (SMI) <1 SD below sex-specific young reference mean (skeletal muscle mass (SMM) by bioelectrical impedance; Visceral fat area (VFA) by MRI)
- Participants
- 1,496 adults
- Exposure
- Baseline serum A-FABP level and its changes, in relation to presarcopenia incidence and improvement
- Outcome
- Incidence and improvement of presarcopenia
- Follow-up
- Average 2.1 years
Methodological detailscommunity-based
- Community-based
Main finding
As reported in the abstract
Incidence of presarcopenia, SMM standardized by weight: RR
3.22 (1.96-5.38) (95% CI)
Incidence of presarcopenia, SMM standardized by VFA: RR
2.11 (1.29-3.51) (95% CI)
Improvement of presarcopenia, SMM standardized by weight: RR
0.66 (0.45-0.97) (95% CI)
Improvement of presarcopenia, SMM standardized by VFA: RR
0.71 (0.54-0.94) (95% CI)
Observational data: associations, not effects.
Further findings
- Changes in serum A-FABP provided additional information on incidence and improvement of presarcopenia, independent of baseline level
- all P < .05
Original publication
Association of Initial and Changes in Serum A-FABP Level With the Development and Improvement of Presarcopenia. J Clin Endocrinol Metab. Published 4 August 2024. doi:10.
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