Associations of Mid- and Late-Life Severe Hypoglycemic Episodes With Incident Dementia Among Patients With Type 2 Diabetes: A Population-Based Cohort Study
Authors' conclusion
Both mid- and late-life hypoglycemia were associated with approximately double the risk of dementia, indicating the need for prevention throughout the life course of those with diabetes.
Study context
- Population
- Patients age ≥40 years with incident T2D, Population Data BC; midlife cohort (age 45–64 years) and late-life cohort (age 65–84 years)two cohorts
- Exposure
- Severe hypoglycaemia vs no severe hypoglycaemia, in mid- and late-life cohorts
- Outcome
- Incident dementia
Methodological detailspropensity score weighting, time-dependent exposure, cause-specific hazards models with death as competing risk
- Propensity score weighting
- Time-dependent exposure
- Cause-specific hazards models with death as competing risk
Main finding
As reported in the abstract
Dementia
Hypoglycemia vs No hypoglycemiaHazard ratio (95% CI)
Midlife cohort
2.85(1.72–4.72)
Late-life cohort
2.38(1.83–3.11)
- Midlife cohort: patients; first severe hypoglycemic event; dementia outcomes (among exposed); median follow-up 9.14 years
- 221,683; 1,793; 3,117 (32)
- Late-life cohort: patients; first severe hypoglycemic event; dementia outcomes (among exposed); median follow-up 6.7 years
- 223,940; 2,466; 15,997 (158)
Observational data: associations, not effects.
Original publication
Associations of Mid- and Late-Life Severe Hypoglycemic Episodes With Incident Dementia Among Patients With Type 2 Diabetes: A Population-Based Cohort Study. Diabetes Care. Published 14 December 2022. doi:10.
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