Associations of body mass index trajectory, waist circumference trajectory, or both with type 2 diabetes mellitus risk in Chinese adults: The China‐PAR project
Authors' conclusion
This study suggests that simultaneous dynamic and continuous monitoring of BMI and WC may contribute more than single measurements to predicting T2DM risk and determining preventive strategies.
Study context
- Population
- Chinese adults in the China-PAR project measured on at least two occasions; 39.21% men39.21% men
- Participants
- 54,434 adults
- Exposure
- Body mass index (BMI) and waist circumference (WC) trajectory groups vs low trajectory groups
- Outcome
- T2D risk
Methodological detailslatent mixed modelling of trajectories, logistic regression
- Latent mixed modelling of trajectories
- Logistic regression
Main finding
As reported in the abstract
T2D risk by BMI or WC trajectory
Odds ratio (CI)
High BMI trajectoryvs Low BMI trajectory
2.85(2.59–3.14)
High WC trajectoryvs Low WC trajectory
4.34(3.78–4.99)
- T2D risk increased with elevated BMI or WC trajectory levels
- all ptrend <0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| T2D risk, joint WC and BMI trajectoryModerate-high/high WC + high BMI trajectoryvs Low WC + low BMI trajectoryHighest risk | 3.96 (3.48–4.50) | |
| T2D risk, joint WC and BMI trajectoryModerate-high/high WC + low BMI trajectoryvs Low WC + low BMI trajectory | 3.00 (2.31–3.91) | |
| 0.20.5125Odds ratio (log scale) |
Interaction with age
- Association more pronounced among younger individuals
- P for interaction < 0.001
Original publication
Associations of body mass index trajectory, waist circumference trajectory, or both with type 2 diabetes mellitus risk in Chinese adults: The China‐PAR project. Diabetes Obes Metab. Published 28 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →