Associations Between Modifiable Risk Factors and Changes in Glycemic Status Among Individuals With Prediabetes
Authors' conclusion
More favorable modifiable factors were related to a higher probability of returning to normoglycemia and a lower probability of progression to type 2 diabetes.
Study context
- Population
- Individuals with prediabetes defined by fasting blood glucose and HbA1c, Health Examinees-Gem study
- Participants
- 10,358 individuals
- Exposure
- Modifiable risk factors vs their absence
- Outcome
- Changes in glycemic status: normoglycemia reversion and T2D progression
- Follow-up
- Median 4 years (range, 1-7 years)
Main finding
As reported in the abstract
Normoglycemia reversion
- BMI ≥25 kg/m², aOR
- 0.71 (95% CI 0.63-0.79)
- Abdominal obesity, OR
- 0.76 (95% CI 0.68-0.86)
- Heavy drinking, OR
- 0.74 (95% CI 0.60-0.91)
- Hypertension, OR
- 0.71 (95% CI 0.64-0.79)
- Dyslipidemia, OR
- 0.78 (95% CI 0.70-0.85)
- More favorable modifiable factors, OR
- 1.46 (95% CI 1.30-1.64)
Observational data: associations, not effects.
Further findings
T2D progression
- BMI ≥25 kg/m², OR
- 1.58 (95% CI 1.29-1.94)
- Abdominal obesity, OR
- 1.31 (95% CI 1.11-1.55)
- Current smoking, OR
- 1.43 (95% CI 1.07-1.91)
- Hypertension, OR
- 1.26 (95% CI 1.07-1.49)
- More favorable modifiable factors, OR
- 0.62 (95% CI 0.49-0.77)
Original publication
Associations Between Modifiable Risk Factors and Changes in Glycemic Status Among Individuals With Prediabetes. Diabetes Care. Published 10 January 2023. doi:10.
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