Associations Between Metabolic Obesity Phenotypes and Pathological Characteristics of Papillary Thyroid Carcinoma
Authors' conclusion
The concurrent presence of obesity and metabolic dysregulation is often connected to more aggressive pathological features in PTC. The mediation analysis suggests obesity directly affects tumor size and indirectly influences tumor multifocality via low high-density lipoprotein cholesterol levels.
Study context
- Population
- Adults with Papillary Thyroid Carcinoma (PTC), Shandong Provincial Hospital
- Participants
- 855 adults
- Exposure
- Metabolic obesity phenotypes vs metabolically healthy nonobese
- Outcome
- Pathological characteristics of PTC
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- MUO vs MHNO: significantly associated with elevated risk of larger tumor size and greater number of tumor foci
- Logistic regression
Observational data: associations, not effects.
Further findings
Mediation analysis
- Obesity directly influences tumor size; its effect on tumor multifocality is mediated through metabolic dysfunctions
- HDL-C levels notably associated with tumor multifocality in obese subjects, mediating obesity's impact on this trait
Original publication
Associations Between Metabolic Obesity Phenotypes and Pathological Characteristics of Papillary Thyroid Carcinoma. Endocr Pract. Published 26 April 2024. doi:10.
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