Associations between inflammatory indices derived from complete blood counts and mortality risk in diabetes and prediabetes patients: A cohort study from National Health and Nutrition Examination Survey (NHANES) 1999--2018
Authors' conclusion
Inflammatory indices such as the SII, SIRI, and NLR are significantly associated with all-cause and CVD mortality among U.S. adults with diabetes and prediabetes, demonstrating index-specific association patterns and threshold characteristics.
Study context
- Population
- Individuals with diabetes and prediabetes, U.S. adults (NHANES); average age 60 years, ≈52 % male
- Participants
- 12,119 individuals
- Outcome
- All-cause, CVD and diabetes-specific mortality
Methodological detailsNHANES data, Cox proportional hazards model
- NHANES data
- Cox proportional hazards model
Main finding
As reported in the abstract
Associations of nine blood count-derived inflammatory indices with mortality
- Overall mortality rate during follow-up
- 25.7 %
- All nine inflammatory indices significantly associated with all-cause mortality and cardiovascular disease (CVD) mortality
- P < 0.01
- Indices correlated with diabetes-specific mortality
- 7
- Indices with significant nonlinear relationships with all-cause mortality (all except NPR)
- 8
Observational data: associations, not effects.
Original publication
Associations between inflammatory indices derived from complete blood counts and mortality risk in diabetes and prediabetes patients: A cohort study from NHANES 1999--2018. Diabetes Res Clin Pract. Published 21 January 2026. doi:10.
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