Indices of obesity, malnutrition and inflammation are strong predictors of mortality in adults with type 2 diabetes: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
Authors' conclusion
MVX independently predicts total and cardiovascular mortality in type 2 diabetes, offering prognostic value beyond traditional risk factors.
Study context
- Population
- Adults with T2D followed for 5 years in the FIELD study; indices derived from baseline plasma NMR
- Participants
- 9,550 adults
- Comparison
- MVX quintiles
- Primary endpoint
- Total mortality
- Follow-up
- 5 years
Methodological detailsCox models adjusted for clinical variables and treatment allocation, NMR-based metabolomic indices
- Cox models adjusted for clinical variables and treatment allocation
- NMR-based metabolomic indices
Primary result
As reported in the abstract
Adjusted hazard ratio (95% CI)
MVX Q5highestvs reference quintile
2.31(1.71–3.12)
Higher mortality risk, % (95% CI)P value
MVX per SD increase
75(62–89)
P < 0.001Per SD increase, as printed
Further findings
| Outcome | C statistic | P value |
|---|---|---|
| Risk model discriminationModel with MVX vs Model without MVX | 0.725 to 0.737 | P = 0.0003 |
Cause-specific mortality and non-fatal events
- MVX associated with cardiovascular and cancer mortality separately, and independently predicted non-fatal cardiovascular events and new incident cancer
- MMX and IVX showed weaker and less consistent associations
Risk model discrimination
- MVX outperformed prior CVD history as a predictor
Original publication
Indices of obesity, malnutrition and inflammation are strong predictors of mortality in adults with type 2 diabetes: the FIELD study. Diabetologia. Published 17 September 2026. doi:10.
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