Associations between coexposure to bisphenols mixture and metabolic diseases: based on three statistical models
Authors' conclusion
Three statistical methods confirmed that BPA and its substitutes were associated with specific MDs. Our findings indicate that coexposure to bisphenols significantly increases the risk of obesity and hypertension.
Study context
- Population
- Participants from the National Health and Nutrition Examination Survey (NHANES)
- Participants
- 1,409 participants
- Exposure
- Coexposure to Bisphenol A (BPA) and its substitutes and metabolic diseases
- Outcome
- Comprehensive metabolic diseases (MDs), related indicators and their multimorbidity
Methodological detailsNHANES, generalized linear regression, Bayesian kernel machine regression and weighted quantile sum (WQS) models
- NHANES
- Generalized linear regression, Bayesian kernel machine regression and weighted quantile sum (WQS) models
Main finding
As reported in the abstract
Associations of bisphenol concentrations with MDs
- Logistic regression: BPA and bisphenol F each independently associated with obesity
- Logistic regression: BPA and BPS each independently associated with multimorbidity
- Bayesian kernel machine regression: joint effects of the three chemicals positively associated with hypertension and obesity; BPS had the highest posterior inclusion probability
- WQS regression: WQS index significantly associated with obesity and hypertension; BPS the highest contributor to both
Observational data: associations, not effects.
Original publication
Associations between coexposure to bisphenols mixture and metabolic diseases: based on three statistical models. Obesity (Silver Spring). Published 10 July 2025. doi:10.
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