Consumption of methyl donor nutrients and incidence of obesity: is the association influenced by parent’s obesity? Results of 4 years of follow-up of the CUME study
Main finding · Incident obesityResult — go to the resultHazard ratio 0.40 95% CI 0.18–0.84Authors' conclusion
Intermediate consumption of B2, B9, and choline was associated with a lower risk of obesity, while a high MetD score was associated with reduced risk of outcome in those with a history of paternal obesity.
Study context
- Population
- Participants of the Cohort of Universities of Minas Gerais (CUME study), 2016–2020; MetD intake (B2, B6, B9, B12, choline, betaine, methionine) by semi-quantitative food frequency questionnaire
- Participants
- 1,205 participants
- Exposure
- Methyl donor nutrient score tertiles: intermediate and high vs low
- Outcome
- Incidence of obesity
- Follow-up
- 4-year follow-up
Methodological details4-year follow-up, Cox regression
- 4-year follow-up
- Cox regression
Main finding
Incident obesity
Hazard ratio
0.40
95% CI 0.18–0.84
Intermediate MetD scorevs Low MetD score
HR 0.40 (95% CI 0.18–0.84)
As reported in the abstract
- Incident obesity cases during follow-up
- 89 (7.4%)
- High MetD score associated with obesity incidence only among those with paternal history of obesity (HR; 95%CI; p-interaction)
- HR: 0.19; 95%CI: 0.03-0.98; p-interaction = 0.022
Observational data: associations, not effects.
Further findings
Individual MetD nutrients (quartiles of intake) and obesity risk · 4-year follow-up
- Third quartile of B2 consumption: less risk of obesity
- 60% (95%CI: 0.20-0.79)
- Second quartile of B9 consumption: less risk of obesity
- 52% (95%CI: 0.26-0.89)
- Second quartile of choline consumption: less risk of obesity
- 52% (95%CI: 0.24-0.93)
Original publication
Consumption of methyl donor nutrients and incidence of obesity: is the association influenced by parent’s obesity? Results of 4 years of follow-up of the CUME study. Int J Obes (Lond). Published 9 July 2025. doi:10.
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