Association of the visceral adiposity index with prediabetes remission to normoglycemia in middle-aged and older Chinese adults: a prospective cohort study
Authors' conclusion
VAI is a key metabolic indicator associated with prediabetes remission, with lower visceral adiposity levels being linked to a higher probability of remission. The threshold of 2.157 identified in this study serves as a potential reference value for risk stratification, warranting further validation in future prospective clinical trials.
Study context
- Population
- Middle-aged and older Chinese adults with prediabetes, CHARLS database
- Participants
- 2,859 participants
- Exposure
- Association of Visceral Adiposity Index's (VAI) with prediabetes remission
- Outcome
- Prediabetes remission: return to normoglycemia
- Follow-up
- Single five-year assessment
Methodological detailslongitudinal, multivariable logistic regression, restricted cubic spline models
- Longitudinal
- Multivariable logistic regression
- Restricted cubic spline models
Main finding
As reported in the abstract
Association of VAI with prediabetes remission · five-year follow-up
Remission
56.28%
VAI and remission, adjusted OR
OR = 0.960
P = 0.017
L-shaped nonlinear relationship (RCS)
P for nonlinearity < 0.001
Inflection-point threshold of VAI
2.157
Observational data: associations, not effects.
Further findings
Subgroup analyses by age
- VAI had stronger predictive performance among individuals aged 60-70 years
Original publication
Association of the visceral adiposity index with prediabetes remission to normoglycemia in middle-aged and older Chinese adults: a prospective cohort study. Diabetes Res Clin Pract. Published 24 March 2026. doi:10.
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