Ancestry-specific genetics of amino acids and microbiota-related metabolites reveal causal effects on cardiometabolic disease in Chinese populations
Authors' conclusion
These findings offer crucial insights into the ancestry-specific genetic determinants of metabolic traits, and shed new light on their causal roles in the etiology of cardiometabolic diseases in East Asian populations.
Study context
- Population
- Chinese individuals in a prospective cohort; 28 serum amino acids (AAs) and 22 microbiota-related metabolites (MRMs); 25 cardiometabolic diseases from the BioBank Japan
- Participants
- 2,953 individuals
- Outcome
- Genetic associations and causal effects of AAs and MRMs on cardiometabolic disease
Methodological detailsprospective cohort, cross-ancestry comparison
- Prospective cohort
- Cross-ancestry comparison
Main finding
As reported in the abstract
Metabolite-variant associations identified
33
Previously unreported metabolite-variant associations
22
Causal relationships between metabolite levels and cardiometabolic diseases (colocalization and Mendelian randomization (MR))
49
Observational data: associations, not effects.
Further findings
Genetic regulation in incident T2DM cases vs healthy controls
- Distinct patterns of genetic regulation between T2DM cases and controls; substantial heterogeneity of effects
Original publication
Ancestry-specific genetics of amino acids and microbiota-related metabolites reveal causal effects on cardiometabolic disease in Chinese populations. Cardiovasc Diabetol. Published 24 March 2026. doi:10.
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