Association of plasma proteomics with incident coronary heart disease in individuals with and without type 2 diabetes: results from the population-based KORA study
Authors' conclusion
This study identified novel protein biomarkers associated with incident CHD in individuals with and without T2D and reaffirmed previously reported protein candidates. These findings enhance our understanding of CHD pathophysiology and provide potential targets for prevention and treatment.
Study context
- Population
- Participants of the KORA S4 (discovery) and KORA-Age1 (validation) studies; 233 plasma proteins related to CVD and inflammation measureddiscovery cohort
- Participants
- 1,492 participants
- Exposure
- Plasma proteins and incident coronary heart disease (CHD) in individuals with vs without T2D
- Outcome
- Incident CHD: protein associations (Cox regression, MR) and predictive performance on top of Framingham risk score variables (C-index, cfNRI, IDI)
- Follow-up
- 15.6 years (discovery); 6.9 years (validation)
Methodological detailspopulation-based, discovery and validation cohorts, proteomics (proximity extension assay), Mendelian randomization
- Population-based
- Discovery and validation cohorts
- Proteomics (proximity extension assay)
- Mendelian randomization
Main finding
As reported in the abstract
15.6 years
| Group | Value | Proteins associated with incident CHD | Four-protein-enriched model ΔC-index | Category-free net reclassification index (cfNRI) | Integrated discrimination improvement (IDI) | 12-protein-enriched model ΔC-index |
|---|---|---|---|---|---|---|
| With T2D | 45 events | 2 | 0.017 | 0.253 | 0.051 | |
| Without T2D | 102 events | 29 | 0.462 | 0.024 | 0.054 |
Value
With T2D45 events
Without T2D102 events
Proteins associated with incident CHD
With T2D2
Without T2D29
Four-protein-enriched model ΔC-index
With T2D0.017
Without T2D— not stated in the abstract
Category-free net reclassification index (cfNRI)
With T2D0.253
Without T2D0.462
Integrated discrimination improvement (IDI)
With T2D0.051
Without T2D0.024
12-protein-enriched model ΔC-index
With T2D— not stated in the abstract
Without T2D0.054
- Novel candidate proteins for incident CHD
- 6
Observational data: associations, not effects.
Further findings
| Outcome | With T2D | Without T2D |
|---|---|---|
| CHD prediction in validation cohort (KORA-Age1, n=888, 70 incident CHD cases); significant improvements only for selected performance measures · 6.9 years | ||
| cfNRI | 0.633 | 0.465 |
| ΔC-index | — not stated in the abstract | 0.038 |
— not stated in the abstract
Original publication
Association of plasma proteomics with incident coronary heart disease in individuals with and without type 2 diabetes: results from the population-based KORA study. Cardiovasc Diabetol. Published 3 February 2024. doi:10.
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