Associations of plasma proteomics with type 2 diabetes and related traits: results from the longitudinal KORA S4/F4/FF4 Study
Authors' conclusion
We identified new candidates involved in the development of derangements in glucose metabolism and type 2 diabetes and confirmed previously reported proteins. Our findings underscore the importance of proteins in the pathogenesis of type 2 diabetes and the identified putative proteins can function as potential pharmacological targets for diabetes treatment and prevention.
Study context
- Population
- Participants of the KORA S4 cohort study (Augsburg region); 233 plasma proteins measured at baseline; median follow-up 13.5 years1,143 in longitudinal analysis
- Participants
- 1,653 participants
- Outcome
- Associations of plasma proteins with prevalent prediabetes, prevalent newly diagnosed T2D and incident T2D
- Follow-up
- Median 13.5 years
Methodological detailscross-sectional and longitudinal analyses, two-sample Mendelian randomisation, priority-Lasso prediction models
- Cross-sectional and longitudinal analyses
- Two-sample Mendelian randomisation
- priority-Lasso prediction models
Main finding
As reported in the abstract
Proteins associated with prevalent prediabetes
14
Proteins associated with prevalent newly diagnosed T2D
24
Proteins associated with incident T2D
4
Overlapping proteins
28
Observational data: associations, not effects.
Further findings
Longitudinal change in glycaemic traits
- Lipoprotein lipase (LPL) linked with change in glucose-related traits; IGFBP2 and PON3 with changes in both insulin- and glucose-related traits
Mendelian randomisation
- Suggested causal effects of LPL on T2D and fasting insulin
Prediction: addition of 12 priority-Lasso-selected biomarkers to Framingham-Offspring Risk Score components
- ΔAUC (95% CI 0.0052, 0.0624); significantly improved predictive performance
- 0.0219
Original publication
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