Lipids & metabolic liver disease
Association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population
Authors' conclusion
This study established a significant association between the TyG index and all-cause and cardiovascular mortality in the general population, particularly among individuals aged < 65. Notably, a non-linear association with all-cause mortality was observed in those aged < 65, while a linear relationship with cardiovascular mortality was found.
Study context
- Population
- General population, National Health and Nutrition Examination Survey (2009–2018)
- Participants
- 20,194 participants
- Exposure
- Higher vs lower Triglyceride-glucose (TyG) index
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 105 months
Methodological detailsNHANES 2009-2018, multivariate Cox proportional hazards regression, restricted cubic splines
- NHANES 2009-2018
- Multivariate Cox proportional hazards regression
- Restricted cubic splines
Main finding
As reported in the abstract
- All-cause mortality
- 13.345%
- Cardiovascular mortality
- 3.387%
- Kaplan-Meier: higher all-cause and CV mortality with higher TyG index
- both P for log-rank test < 0.001
- Cox, adjusted: no linear trend, all-cause mortality
- P for trend = 0.424
- Cox, adjusted: no linear trend, CV mortality
- P for trend = 0.481
- Non-linear association (restricted cubic splines), all-cause mortality
- Non-linear P = 0.003
- Non-linear association (restricted cubic splines), CV mortality
- Non-linear P = 0.034
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Predictive performance, TyG index vs HOMA-IRTyG index vs HOMA-IR · all-cause mortality: 0.620 vs. 0.524 · ROC curves | P < 0.001 |
| Predictive performance, TyG index vs HOMA-IRTyG index vs HOMA-IR · CV mortality: 0.623 vs. 0.537 · ROC curves | P < 0.001 |
Subgroup interaction
- Consistent across most subgroups, all-cause mortality
- P for interaction = 0.077-0.940
- Consistent across most subgroups, CV mortality
- P for interaction = 0.173-0.987
- Age subgroup interaction, all-cause mortality
- P for interaction < 0.001
- Age subgroup interaction, CV mortality
- P for interaction < 0.001
Age-specific analysis, aged < 65 vs ≥ 65
- Aged < 65: non-linear association with all-cause mortality
- Non-linear P = 0.011
- Aged < 65: linear upward relationship with CV mortality
- Non-linear P = 0.742, P for trend = 0.010
- Association remained significant in aged < 65 but not in aged ≥ 65
Aged 45-64
- All-cause mortality
- Non-linear P = 0.001
- CV mortality
- Non-linear P = 0.902, P for trend = 0.015
Original publication
Association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population. Cardiovasc Diabetol. Published 22 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →