Lipids & metabolic liver disease
Association of triglyceride glucose index and triglyceride glucose-body mass index with sudden cardiac arrest in the general population
Authors' conclusion
Higher TyG index and TyG-BMI levels are associated with an increased SCA risk and earlier onset, particularly in women.
Study context
- Population
- UK Biobank participants with available triglyceride glucose (TyG) index and triglyceride glucose-body mass index (TyG-BMI) data and no history of cardiovascular disease (CVD)1,622 sudden cardiac arrest (SCA) cases
- Participants
- 355,242 participants
- Exposure
- Higher vs lower TyG index and TyG-BMI
- Outcome
- Sudden cardiac arrest (SCA)
- Follow-up
- Median 165.4 months (IQR 156.5-174 months)
Methodological detailsUK Biobank, Cox proportional risk models, Accelerated Failure Time models, restricted cubic spline
- UK Biobank
- Cox proportional risk models
- Accelerated Failure Time models
- Restricted cubic spline
Main finding
As reported in the abstract
SCA risk
aHR per SD increase in TyG index
1.09
95% CI 1.04–1.15
aHR per SD increase in TyG-BMI
1.14
95% CI 1.09–1.2
Observational data: associations, not effects.
Further findings
Timing of SCA onset (Accelerated Failure Time (AFT) models)
- Earlier median times to SCA with increasing quintiles of TyG index and TyG-BMI vs lowest quintile
- P for trend < 0.05
Dose-response with gradual increases (restricted cubic spline)
- Linear correlation of SCA risk with TyG index
- P = 0.54
- Non-linear correlation of SCA risk with TyG-BMI
- P = 0.007
Sex-stratified analyses
- Stronger associations in women
Original publication
Association of triglyceride glucose index and triglyceride glucose-body mass index with sudden cardiac arrest in the general population. Cardiovasc Diabetol. Published 18 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →