Association of relative fat mass with the incidence of type 2 diabetes: over a decade follow-up from the TLGS
Authors' conclusion
While RFM is strongly associated with the risk of T2DM, particularly in women and younger individuals, it does not outperform WC.
Study context
- Population
- Adults in the Tehran Lipid and Glucose Study cohort; 4716 women; mean age 40.52 years
- Participants
- 8,419 adults
- Exposure
- Per SD increase in relative fat mass (RFM)
- Outcome
- Incident T2D
- Follow-up
- Median 14 years
Methodological detailspopulation-based cohort (Tehran Lipid and Glucose Study)
- Population-based cohort (Tehran Lipid and Glucose Study)
Main finding
As reported in the abstract
Incident T2D per SD increase in RFM (multivariable-adjusted)
Hazard ratio (CI)P value
Men: per SD increase in RFM
1.26(1.02–1.57)
P = 0.037Women: per SD increase in RFM
1.52(1.27–1.81)
P < 0.001Per SD increase in RFM, as printed
- Developed T2D
- 1382 (16.42%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| RFM vs WC for T2D riskComparable in men and women | P for difference > 0.05 |
Baseline insulin resistance, metabolic syndrome and its components
- RFM significantly associated with insulin resistance, metabolic syndrome and its components in both men and women
Subgroups and sensitivity analyses
- Associations stronger in younger individuals
- Remained significant only in women after adjusting for insulin resistance and restricting to normoglycemic individuals
Original publication
Association of relative fat mass with the incidence of type 2 diabetes: over a decade follow-up from the TLGS. Int J Obes (Lond). Published 8 September 2025. doi:10.
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