Association of Physical Activity Patterns With Nocturnal Hypoglycemia Events in Youth With Type 1 Diabetes
Authors' conclusion
Daily VPA is associated with glucose reductions, potentially leading to more hypoglycemic episodes, particularly when there is an excess of daily insulin. This highlights the need for careful insulin management in children and adolescents with type 1 diabetes engaging in VPA.
Study context
- Population
- Children and adolescents aged 6 to 18 years with T1D (43.9% girls), Diactive-1 Cohort Study; CGM, accelerometry, daily insulin doses and carbohydrate counting over 7 days574 measurement days
- Participants
- 82 children
- Exposure
- Physical activity (PA) patterns vs mean glucose and nocturnal hypoglycaemia events
- Outcome
- Associations of PA with mean glucose and nocturnal hypoglycaemia events
Methodological detailsDiactive-1 Cohort Study
- Diactive-1 Cohort Study
Main finding
As reported in the abstract
- Participants with ≥1 nocturnal hypoglycaemia event
- 19
- Days with nocturnal hypoglycaemia
- 106
- Days without nocturnal hypoglycaemia
- 451
- Higher vigorous PA (VPA) associated with lower same-day mean glucose
- P = .014
- Higher moderate PA associated with more nocturnal hypoglycaemia events
- P = .023
- Higher VPA associated with more nocturnal hypoglycaemia events
- P = .011
- Higher moderate-to-vigorous PA associated with more nocturnal hypoglycaemia events
- P = .010
Observational data: associations, not effects.
Further findings
- Significant association between VPA and nocturnal hypoglycaemia events when daily insulin dose ≥1.04 units/kg/day
- P = 0.016
Original publication
Association of Physical Activity Patterns With Nocturnal Hypoglycemia Events in Youth With Type 1 Diabetes. J Clin Endocrinol Metab. Published 2 July 2024. doi:10.
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