Association of Life's Essential 8 with abdominal aortic calcification and mortality among middle‐aged and older individuals

Ni, G; Jia, Q; Li, Y; Cheang, I; Zhu, X; Zhang, H; Li, X

doi:10.1111/dom.15854

Association of Life's Essential 8 with abdominal aortic calcification and mortality among middle‐aged and older individuals

Diabetes Obes MetabPublished 20 Aug 2024Cross-sectional and prospective cohort study

Main finding · Prevalence of AACResultOdds ratio 2.12 CI 1.12–4.19

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Authors' conclusion

The LE8 score correlates with AAC prevalence in middle-aged and older individuals and serves as a valuable tool for evaluating the risk of all-cause and cardiovascular mortality in individuals with AAC.

Study context

Population: Participants aged >40 years, NHANES 2013–2014; Abdominal aortic calcification (AAC) assessed by DXA
Participants: 2,567 participants

Exposure: Low and medium vs high LE8 scores; AAC vs no AAC
Outcome: Prevalence of AAC

Methodological detailsNHANES 2013-2014, mortality linkage with National Death Index

NHANES 2013-2014
Mortality linkage with National Death Index

Main finding

As reported in the abstract

Odds ratio

2.12

CI 1.12–4.19

Low LE8vs High LE8

OR 2.12 (CI 1.12–4.19)

Mean LE8 score: 67.28 ± 0.48
AAC prevalence: 28.28%

Observational data: associations, not effects.

Further findings

Outcome	← Lower risk with AAC ←→ Higher risk with AAC →	HR (CI)
All-cause and CV mortality, AAC vs no AAC · median 6-year follow-upAACvs No AACAll-cause mortality	0.20.5125	2.17 (1.60–2.95)
All-cause and CV mortality, AAC vs no AAC · median 6-year follow-upAACvs No AACCV mortality	0.20.5125	2.35 (1.40–3.93)
	0.20.5125Hazard ratio (log scale)

Mortality in AAC with low or medium LE8 scores · median 6-year follow-up

	← Lower risk ←→ Higher risk →	HR (CI)
AAC + Low LE8All-cause mortality; 137% higher risk	0.10.31310	2.37 (1.58–3.54)
AAC + Medium LE8All-cause mortality; 119% higher risk	0.10.31310	2.19 (1.61–2.99)
AAC + Low LE8CV mortality; 224% increased risk	0.10.31310	3.24 (1.73–6.04)
AAC + Medium LE8CV mortality; 125% increased risk	0.10.31310	2.25 (1.24–4.09)
	0.10.31310Hazard ratio (log scale)

All-cause and CV mortality, AAC vs no AAC — All-cause deaths: 222
All-cause and CV mortality, AAC vs no AAC — CV deaths: 55

Original publication

Association of Life's Essential 8 with abdominal aortic calcification and mortality among middle‐aged and older individuals. Diabetes Obes Metab. Published 20 August 2024. doi:10.1111/dom.15854

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