Association of large for gestational age with cardiovascular metabolic risks: a systematic review and meta‐analysis
Authors' conclusion
LGA is associated with increased odds of obesity and metabolic syndrome later in life. Future studies should focus on elucidating the potential mechanisms and identifying risk factors.
Study context
- Population
- Individuals born large for gestational age (LGA) or appropriate for gestational age; studies of BMI, blood pressure, glucose metabolism and lipid profiles (PubMed, Web of Science, Cochrane Library)
- Participants
- 841,325 individuals42 studies
- Comparison
- Born LGA vs born appropriate for gestational age
- Outcome
- Cardiometabolic risk factors
Methodological detailsrandom-effects model, Quality assessed with Newcastle-Ottawa Scale; publication bias by funnel graph
- Random-effects model
- Quality assessed with Newcastle-Ottawa Scale; publication bias by funnel graph
Pooled result
As reported in the abstract
Each group vs appropriate for gestational ageEstimate (95% CI)
LGA
OR, overweight and obesity 1.44(1.31–1.59)
LGA
OR, T1D 1.28(1.15–1.43)
LGA
OR, hypertension 1.23(1.01–1.51)
LGA
OR, metabolic syndrome 1.43(1.05–1.96)
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| Overweight and obesity, stratified by ageLGAvs Appropriate for gestational age | OR, toddler age 2.12 (95% CI 1.22–3.70) | |
| Overweight and obesity, stratified by ageLGAvs Appropriate for gestational age | OR, preschool 1.81 (95% CI 1.55–2.12) | |
| Overweight and obesity, stratified by ageLGAvs Appropriate for gestational age | OR, school age 1.53 (95% CI 1.09–2.14) | |
| Overweight and obesity, stratified by ageLGAvs Appropriate for gestational age | OR, puberty 1.40 (95% CI 1.11–1.77) | |
| 0.20.5125Ratio (log scale) |
Original publication
Association of large for gestational age with cardiovascular metabolic risks: a systematic review and meta‐analysis. Obesity (Silver Spring). Published 26 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →